- Millipore Corporation is the Town’s largest employer, providing over 500 jobs.
- Teleflex Corporation recently completed a climate controlled clean room – supporting an additional 65 jobs.
- Jaffrey is the home of Mt. Monadnock; the State Park receives more than 100,000 visitors a year and is a National Natural Landmark.
- D. D. Bean & Sons, the largest manufacturer of paper book matches in the U.S., is located in Jaffrey. Atlas Pyrovision Productions, headquartered on Old Sharon Road in Jaffrey, has won competitions throughout the world for its dazzling fireworks displays.
- New England Wood Pellet, also headquartered on Old Sharon Road, is the largest wood pellet manufacturer in the United States.
- Zilkha Biomass – research and development of electricity co-generation facilities has partnered with NE Wood Pellets for the first commercial installation of Zilkha's direct-fired, wood-fuel gas turbine power plant.